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Cardinal sign (pathology)
In pathology, a cardinal sign or cardinal symptom is the primary or major clinical sign symptom by which a diagnosis is made.〔(yourdictionary.com > cardinal symptom definition - medical ) Citing: The American Heritage Medical Dictionary. Copyright 2009 by Houghton Mifflin Harcourt Publishing Company.〕
A cluster of signs or symptoms are often combined (pathognomonic) to better diagnose a specific disease or syndrome.
==Examples==
Inflammation is characterized by five cardinal signs:
* ''rubor'' (redness),
* ''calor'' (increased heat),
* ''tumor'' (swelling),
* ''dolor'' (pain), and
* ''functio laesa'' (loss of function).
The first four signs were first established by Aulus Cornelius Celsus in his work ''De Medicina'' (1st Century DC), and are known by the name ''Celsus tetrad''.
In acute exacerbations of chronic bronchitis, diagnosis is normally based on the three cardinal signs of:〔(The British Society for Antimicrobial Chemotherapy > Acute exacerbations of chronic bronchitis (AECB) ) Retrieved on Mars 13, 2010〕
* Increased shortness of breath
* Increased sputum volume
* Purulent sputum
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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